Cadherin 5 Protein (CDH5) (AA 25-599) (His tag)
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- Antigène Voir toutes Cadherin 5 (CDH5) Protéines
- Cadherin 5 (CDH5)
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 25-599
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Origine
- Souris
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette Cadherin 5 protéine est marqué à la His tag.
- Séquence
- Gly 25-Gln 599
- Attributs du produit
- A DNA sequence encoding the Mouse Cdh5 protein (P55284) (Gly 25-Gln 599) was expressed with a N-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CDH5 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- Cadherin 5 (CDH5)
- Autre désignation
- Cdh5 (CDH5 Produits)
- Synonymes
- 7B4 Protein, AA408225 Protein, Cd144 Protein, VE-Cad Protein, VECD Protein, VEcad Protein, Vec Protein, wu:fc88a07 Protein, CD144 Protein, cadherin-5 Protein, cadherin 5 Protein, CDH5 Protein, Cdh5 Protein, cdh5 Protein
- Sujet
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Abbreviation: Cdh5
Target Synonym: 7B4,AA408225,Cd144,VE-Cad,Vec,VEcad,VECD,Cdh5
Background: Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
- Poids moléculaire
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Calculated MW: 63.14 kDa
Observed MW: 65 kDa
- UniProt
- P55284
- Pathways
- Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2
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