Ceruloplasmin Protein (AA 729-1061) (His tag)

N° du produit ABIN7505385

Détail du produit

Antigène: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Type de proteíne: Recombinant

Attributs du protein: AA 729-1061

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Ceruloplasmin protéine est marqué à la His tag.

Séquence: Tyr729-Gly1061

Attributs du produit: A DNA sequence encoding the Mouse CP protein (Q61147) (Tyr729-Gly1061) was expressed with a N-His .

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Autre désignation: Ceruloplasmin (CP Produits)

Synonymes: CP-2 Protein, fi23f10 Protein, wu:fi23f10 Protein, D3Ertd555e Protein, CERP Protein, CP Protein, ceruloplasmin Protein, CP Protein, cp Protein, Cp Protein, LOC100533122 Protein

Sujet:

Abbreviation: Ceruloplasmin,CP

Target Synonym: CERU_MOUSE,EC:1.16.3.1,Ferroxidase

Background: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.

Poids moléculaire:

Calculated MW: 36.52 kDa

Observed MW: 40 kDa

UniProt: Q61147

Pathways: Transition Metal Ion Homeostasis