ACTH Protein (AA 27-235) (His tag)

N° du produit ABIN7505394

Détail du produit

Antigène: ACTH (Adrenocorticotropic hormone (ACTH))

Type de proteíne: Recombinant

Attributs du protein: AA 27-235

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ACTH protéine est marqué à la His tag.

Séquence: Trp 27-Gln 235

Attributs du produit: A DNA sequence encoding the Mouse ACTH protein (P01193) (Trp 27-Gln 235) was expressed with a N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: ACTH (Adrenocorticotropic hormone (ACTH))

Autre désignation: ACTH (ACTH Produits)

Synonymes: ACTH Protein, BE Protein, Beta-LPH Protein, Clip Protein, Gamma-LPH Protein, Npp Protein, Pomc-1 Protein, Pomc1 Protein, alpha-MSH Protein, alphaMSH Protein, beta-MSH Protein, gamma-MSH Protein, CLIP Protein, LPH Protein, MSH Protein, NPP Protein, POC Protein, pro-opiomelanocortin-alpha Protein, proopiomelanocortin Protein, Pomc Protein, POMC Protein

Sujet:

Abbreviation: ACTH

Target Synonym: ACTH,Adrenocorticotropic hormone,Adrenocorticotropin,Pomc,Pomc1,POC,POMC,Pomc-1,Pomc1,Pmc2

Background: Adrenocorticotropic hormone (ACTH)/corticotropin is a 39 amino acid peptide generated by cleavage of the POMC, a preprotein which also can also be cleaved to produce MSH, Beta-endorphin and Met-enkephalin, depending on tissue expression and context. ACTH is a ligand for the ACTH receptor, also known as melanocortin receptor 2. ACTH is secreted by the anterior pituitary gland upon stimulation by corticotropin-releasing hormone (CRH) which is secreted by the hypothalamus. The principal effect of ACTH is production of cortisol by the adrenal gland but it also mediates bone formation and osteoblast survival. ACTH has been shown to induce insulin resistance in adipocytes and promote pro-inflammatory adipokine secretion.

Poids moléculaire:

Calculated MW: 22.88 kDa

Observed MW: 30 kDa

UniProt: P01193

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity