FGA Protein (AA 434-789) (His tag)

N° du produit ABIN7505430

Détail du produit

Antigène: FGA (Fibrinogen alpha Chain (FGA))

Type de proteíne: Recombinant

Attributs du protein: AA 434-789

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette FGA protéine est marqué à la His tag.

Séquence: Asp 434-Gln 789

Attributs du produit: A DNA sequence encoding the Mouse FGA protein (E9PV24 ) (Asp 434-Gln 789) was expressed with N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: FGA (Fibrinogen alpha Chain (FGA))

Autre désignation: FGA (FGA Produits)

Synonymes: Fib2 Protein, ENSMUSG00000059807 Protein, Fib Protein, Ac1873 Protein, Fba5e Protein, fibrinogen alpha chain Protein, FGA Protein, Fga Protein, LOC698244 Protein

Sujet:

Abbreviation: FGA,Fibrinogen A

Target Synonym: FGA,Fib2,Fibrinogen A,Fibrinogen alpha chain,Fibrinogen Type I,fibrinogen,A alpha polypeptide,FPA

Background: Fibrinogen is a 340 kDa, secreted glycoprotein complex that is found in blood at concentrations of 150-400 mg/dL. It is secreted primarily by hepatocytes, but is also reported to be expressed by fibroblasts, type I alveolar epithelium, intestinal epithelium and some tumor cells. Fibrinogen is a homodimer that is composed of two, three-polypeptide chain subunits. Fibrinogen plays a central role in clot formation. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Fibrinogen is also a component of the ECM and binds to cell surface molecules on inflammatory cells. Mature mouse alpha, beta and gamma -chains share 67 % , 85 % and 83 % aa identity with human alpha, beta and gamma -chains, respectively.

Poids moléculaire:

Calculated MW: 39.05 kDa

Observed MW: 50 kDa

UniProt: E9PV24