TIMP2 Protein (AA 27-220) (His tag)
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- Antigène Voir toutes TIMP2 Protéines
- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 27-220
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Origine
- Souris
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette TIMP2 protéine est marqué à la His tag.
- Séquence
- Cys 27-Pro 220
- Attributs du produit
- A DNA sequence encoding the Mouse TIMP-2/TIMP2 protein (P25785) (Cys 27-Pro 220) was expressed with N-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product TIMP2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
- Autre désignation
- TIMP-2 (TIMP2 Produits)
- Synonymes
- CSC-21K Protein, DDC8 Protein, timp2l Protein, zgc:65967 Protein, zgc:85799 Protein, D11Bwg1104e Protein, Timp-2 Protein, TIMP-2 Protein, etID32613.12 Protein, fa96h09 Protein, timp2 Protein, wu:fa96h09 Protein, zgc:136726 Protein, TIMP metallopeptidase inhibitor 2 Protein, TIMP metallopeptidase inhibitor 2b Protein, tissue inhibitor of metalloproteinase 2 Protein, TIMP metallopeptidase inhibitor 2a Protein, TIMP metallopeptidase inhibitor 2 L homeolog Protein, TIMP2 Protein, timp2b Protein, Timp2 Protein, timp2a Protein, timp2.L Protein
- Sujet
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Abbreviation: TIMP-2,TIMP2
Target Synonym: CSC-21Ktissue inhibitor of metalloproteinase 2,metalloproteinase inhibitor 2,TIMP metalloproteinase inhibitor 2,Tissue inhibitor of metalloproteinase 2.
Background: Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.And the interaction with MMP-14 facilitates the activation of pro-MMP-2.It has been shown that the binding of TIMP 2 to a3b1 integrin results in the inhibition of endothelial cell proliferation and angiogenesis.
- Poids moléculaire
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Calculated MW: 21.23 kDa
Observed MW: 25 kDa
- UniProt
- P25785
- Pathways
- cAMP Metabolic Process
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