PSMA Protein (AA 45-335) (His tag)
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- Antigène Voir toutes PSMA (FOLH1) Protéines
- PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 45-335
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Origine
- Souris
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette PSMA protéine est marqué à la His tag.
- Séquence
- Lys 45-Phe 335
- Attributs du produit
- A DNA sequence encoding the mouse PSMA / FOLH1 protein (O35409) (Lys 45-Phe 335) was expressed with N-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product FOLH1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
- Autre désignation
- PSMA (FOLH1 Produits)
- Synonymes
- FGCP Protein, FOLH Protein, GCP2 Protein, GCPII Protein, NAALAD1 Protein, NAALAdase Protein, PSM Protein, PSMA Protein, mGCP Protein, mopsm Protein, Naalad Protein, putative N-acetylated-alpha-linked acidic dipeptidase Protein, folate hydrolase 1B Protein, folate hydrolase 1 Protein, folate hydrolase (prostate-specific membrane antigen) 1 Protein, LOC451185 Protein, FOLH1B Protein, FOLH1 Protein, Folh1 Protein
- Sujet
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Abbreviation: PSMA;FOLH1
Target Synonym: Glutamate carboxypeptidase 2;Folh1;Folate hydrolase 1;Folylpoly-gamma-glutamate carboxypeptidase (FGCP);Glutamate carboxypeptidase II (GCPII);Membrane glutamate carboxypeptidase (mGCP);N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I)
Background: Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type I I membrane protein which belongs to the peptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.
- Poids moléculaire
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Calculated MW: 31.9 kDa
Observed MW: 38 kDa
- UniProt
- O35409
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