IGFBP2 Protein (AA 35-305) (His tag)

N° du produit ABIN7505441

Détail du produit

Antigène: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Type de proteíne: Recombinant

Attributs du protein: AA 35-305

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette IGFBP2 protéine est marqué à la His tag.

Séquence: Glu 35-Gln 305

Attributs du produit: A DNA sequence encoding the Mouse IGFBP-2 / IGFBP2 protein (P47877) (Glu 35-Gln 305) was expressed with N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Autre désignation: IGFBP-2 (IGFBP2 Produits)

Synonymes: IBP2 Protein, IGF-BP53 Protein, AI255832 Protein, IBP-2 Protein, Igfbp-2 Protein, mIGFBP-2 Protein, IGFBP-2 Protein, ILGFBPA Protein, pIGFBP-2 Protein, igfbp2 Protein, MGC65741 Protein, MGC76823 Protein, MGC174445 Protein, IGFBP2 Protein, ibp2 Protein, igf-bp53 Protein, igfbp2a Protein, si:ch211-2k18.3 Protein, insulin like growth factor binding protein 2 Protein, insulin-like growth factor binding protein 2 Protein, insulin-like growth factor binding protein 2a Protein, insulin-like growth factor binding protein 2b Protein, IGFBP2 Protein, Igfbp2 Protein, igfbp2a Protein, igfbp2 Protein, igfbp2b Protein

Sujet:

Abbreviation: IGFBP-2,IGFBP2

Target Synonym: Insulin-like growth factor-binding protein 2, Igfbp2,IBP-2,IGF-binding protein 2,IGFBP-2,mIGFBP-2

Background: IGFBP-2, also known as IGFBP2, is a insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs , control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to a potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates.

Poids moléculaire:

Calculated MW: 29.7 kDa

Observed MW: 39 kDa

UniProt: P47877

Pathways: Myometrial Relaxation and Contraction, Growth Factor Binding, Activated T Cell Proliferation