AIF Protein (AA 150-299) (His tag)
-
- Antigène Voir toutes AIF (AIFM1) Protéines
- AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 150-299
-
Origine
- Rat
-
Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette AIF protéine est marqué à la His tag.
- Séquence
- Arg 150-Val 299
- Attributs du produit
- A DNA sequence encoding the Rat AIF-M1 protein (Q9JM53) (Arg 150-Val 299) was expressed with a N-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product AIFM1 Protéine
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
-
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
-
- Antigène
- AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))
- Autre désignation
- AIF-M1 (AIFM1 Produits)
- Synonymes
- AIF Protein, CMTX4 Protein, COWCK Protein, COXPD6 Protein, PDCD8 Protein, CG7263 Protein, DmAIF Protein, Dmel\\CG7263 Protein, GB16024 Protein, DDBDRAFT_0187853 Protein, DDBDRAFT_0191137 Protein, DDB_0187853 Protein, DDB_0191137 Protein, aif Protein, pdcd8 Protein, AIFM1 Protein, PCD8 Protein, AIFsh2 Protein, Hq Protein, Pdcd8 Protein, mAIF Protein, Aif Protein, zgc:91994 Protein, apoptosis inducing factor mitochondria associated 1 Protein, allograft inflammatory factor 1 Protein, Apoptosis inducing factor Protein, apoptosis-inducing factor 1, mitochondrial Protein, apoptosis inducing factor Protein, apoptosis inducing factor, mitochondria associated 1 Protein, apoptosis-inducing factor, mitochondrion-associated, 1 Protein, apoptosis-inducing factor, mitochondrion-associated 1 Protein, AIFM1 Protein, AIF1 Protein, AIF Protein, LOC412212 Protein, aif Protein, aifm1 Protein, Aifm1 Protein
- Sujet
-
Abbreviation: AIF-M1
Target Synonym: AIFM1,Apoptosis inducing factor 1,mitochondrial,Apoptosis inducing factor,CMTX4,COWCK,COXPD6,Harlequin,mitochondrial,PDCD 8,Programmed cell death 8,Striatal apoptosis inducing factor
Background: Probable oxidoreductase that has a dual role in controlling cellular life and death, during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
- Poids moléculaire
-
Calculated MW: 16.39 kDa
Observed MW: 18 kDa
- UniProt
- Q9JM53
- Pathways
- Apoptose, Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, L'effet Warburg
-