LILRA5 Protein (AA 42-268) (His tag)

N° du produit ABIN7505590

Détail du produit

Antigène: LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))

Type de proteíne: Recombinant

Attributs du protein: AA 42-268

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette LILRA5 protéine est marqué à la His tag.

Séquence: Gly42-Arg268

Attributs du produit: Recombinant Human LILRA5 Member 5 is produced by our Mammalian expression system and the target gene encoding Gly42-Arg268 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: <1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))

Autre désignation: LILRA5 (LILRA5 Produits)

Synonymes: CD85 Protein, CD85F Protein, ILT-11 Protein, ILT11 Protein, LILRB7 Protein, LIR-9 Protein, LIR9 Protein, E030017K20 Protein, EG232801 Protein, Gm4878 Protein, Lilrc1 Protein, leukocyte immunoglobulin like receptor A5 Protein, leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 Protein, LILRA5 Protein, Lilra5 Protein

Sujet:

Abbreviation: LILRA5

Target Synonym: Leukocyte immunoglobulin-like receptor subfamily A member 5,CD85 antigen-like family member F,Immunoglobulin-like transcript 11,ILT-11,Leukocyte immunoglobulin-like receptor 9,LIR-9,CD85f,LILRA5,LILRB7,CD85F,ILT11,LILRB7,LIR-9,LIR9

Background: Leukocyte Immunoglobulin-like Receptor Subfamily A Member 5(LILRA5)is a member of the leukocyte immunoglobulin-like receptors (LILR), comprise a family of activating and inhibitory type immunoreceptors. LILRA5 consists of a 227 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 10 aa cytoplasmic tail. The ECD contains two Ig-like domains and the transmembrane segment contains a positively charged aspartic acid residue which may mediate its association with the signaling molecule, FcR common gamma chain. LILRA5 is expressed by monocytes, macrophages, and neutrophils. Cross-linking of LILRA5 on monocytes induces the expression of pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) as well as the anti-inflammatory IL-10. It can be detected in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Crosslink of ILT-11 on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.

Poids moléculaire:

Calculated MW: 26.1 kDa

Observed MW: 35-40 kDa

UniProt: A6NI73