Glucuronidase beta Protein (AA 1-651) (His tag)

N° du produit ABIN7505644

Détail du produit

Antigène: Glucuronidase beta (GUSB) (Glucuronidase, beta (GUSB))

Type de proteíne: Recombinant

Attributs du protein: AA 1-651

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Glucuronidase beta protéine est marqué à la His tag.

Séquence: Met1-Thr651

Attributs du produit: A DNA sequence encoding the Human GUSβ protein (P08236) (Met1-Thr651) was expressed with a C-His.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Glucuronidase beta (GUSB) (Glucuronidase, beta (GUSB))

Autre désignation: Beta-glucuronidase (GUSB Produits)

Synonymes: GUSB Protein, beta-GUS Protein, gus Protein, BG Protein, MPS7 Protein, AI747421 Protein, Gur Protein, Gus Protein, Gus-r Protein, Gus-s Protein, Gus-t Protein, Gus-u Protein, Gut Protein, asd Protein, g Protein, Ac2-223 Protein, si:ch211-160e1.7 Protein, si:ct573103.7 Protein, glucuronidase beta Protein, beta-D-glucuronidase Protein, beta-glucuronidase Protein, beta glucuronidase Protein, glucuronidase, beta Protein, GUSB Protein, bglR Protein, SSO_RS14735 Protein, Glu Protein, Gusb Protein, gusb Protein

Sujet:

Abbreviation: Beta-glucuronidase,GUSB

Target Synonym: Beta-glucuronidase,EC 3.2.1.31,Beta-G1,GUSB

Background: Human beta -Glucuronidase (EC 3.2.1.31) encoded by the GUSB gene is a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans that include heparan sulfate, chondroitin sulfate and hyaluronan. The enzyme is only active on the glucuronic acid of the non-reducing end. The native protein has been reported as a tetrameric glycoprotein composed of identical subunits. Mutations in the GUSB gene are linked to mucopolysaccharidosis type VII. Accumulation of partially degraded glycosaminoglycans, with glucuronic acid residues at the non-reducing termini, are usually found in the lysosomes of patients with the disease. It has also been reported that this enzyme may contribute to the depletion of chondroitin from cartilage and thereby facilitate the damage of joints in rheumatoid arthritis.

Poids moléculaire:

Calculated MW: 71.5 kDa

Observed MW: 80 kDa

UniProt: P08236

Pathways: Glycosaminoglycan Metabolic Process