IL6RA Protein (AA 1-365) (His tag)
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- Antigène Voir toutes IL6RA Protéines
- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 1-365
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette IL6RA protéine est marqué à la His tag.
- Séquence
- Met1-Pro365
- Attributs du produit
- A DNA sequence encoding the Human IL-6R protein (P08887) (Met1-Pro365) was expressed with a C-His.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product IL6RA Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
- Autre désignation
- IL6RA (IL6RA Produits)
- Synonymes
- IL6R1 Protein, Il6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, Il6r Protein, IL6R Protein, Il6ra Protein
- Sujet
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Abbreviation: IL6RA,CD126
Target Synonym: Interleukin-6 receptor subunit alpha,IL-6R subunit alpha,IL-6R-alpha,IL-6R 1,Membrane glycoprotein 80,gp80,CD126,IL-6R,IL-6R-1,IL-6RA,IL6Q,IL6RQ
Background: Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
- Poids moléculaire
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Calculated MW: 40.04 kDa
Observed MW: 70 kDa
- UniProt
- P08887
- Pathways
- Signalistation JAK/STAT, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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