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Chromogranin A Protein (CHGA) (AA 1-457) (His tag)

CHGA Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
N° du produit ABIN7505660
  • Antigène Voir toutes Chromogranin A (CHGA) Protéines
    Chromogranin A (CHGA)
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 1-457
    Origine
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Source
    • 7
    • 6
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette Chromogranin A protéine est marqué à la His tag.
    Séquence
    Met1-Gly457
    Attributs du produit
    A DNA sequence encoding the Human CHGA protein (P10645) (Met1-Gly457) was expressed with a C-His.
    Pureté
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product CHGA Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Date de péremption
    12 months
  • Antigène
    Chromogranin A (CHGA)
    Autre désignation
    CHGA (CHGA Produits)
    Synonymes
    CGA Protein, CG-ALPHA Protein, FSHA Protein, GPHA1 Protein, GPHa Protein, HCG Protein, LHA Protein, TSHA Protein, ChrA Protein, fj05f09 Protein, si:dkey-177p2.2 Protein, wu:fj05f09 Protein, zgc:101749 Protein, zgc:56075 Protein, CHGA Protein, cgA Protein, chga Protein, chromogranin A Protein, glycoprotein hormones, alpha polypeptide Protein, uncharacterized CHGA Protein, chromogranin A S homeolog Protein, CHGA Protein, CGA Protein, Chga Protein, chga Protein, chga.S Protein
    Sujet

    Abbreviation: CHGA

    Target Synonym: Chromogranin-A,CgA,Pituitary secretory protein I,SP-I,CHGA

    Background: Chromogranin A (CgA), also known as pituitary secretory protein I (SP-I), is a member of the granin family of regulated secretory proteins. CgA shares several protein characteristics common to the granin family: acidic isoelectric point, the capacity to bind calcium ions, the ability to form aggregates and multiple dibasic cleavage sites. Mature human CgA is 439 amino acids (aa) and contains 10 dibasic, proteolytic cleavage sites, capable of yielding several smaller peptides, each displaying a unique function. Mature human CgA shares 63 % aa sequence identity with mouse and rat CgA. CgA is expressed exclusively in the secretory dense core granules of most normal and neoplastic neuroendocrine cells. Increased levels of CgA have been detected inpatients with neuroendocrine tumors as well as non-neuroendocrine tumors, hence CgA is an important serological marker for tumor diagnosis and monitoring tumorprogression/regression. It has been demonstrated in mouse model that full-length CgA containing its C-terminal region can impair angiogenesis and tumor growth. In addition, CgA can bind to Secretogranin III to regulate the biogenesis of secretory granules.

    Poids moléculaire

    Calculated MW: 50.16 kDa

    Observed MW: 75 kDa

    UniProt
    P10645
    Pathways
    Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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