SERPINA6 Protein (AA 1-405) (His tag)
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- Antigène Voir toutes SERPINA6 Protéines
- SERPINA6 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 1-405
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette SERPINA6 protéine est marqué à la His tag.
- Séquence
- Met 1-Val 405
- Attributs du produit
- A DNA sequence encoding the Human CBG/SERPINA6 protein (P08185) (Met 1-Val 405) was expressed with a C-His .
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product SERPINA6 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- SERPINA6 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6))
- Autre désignation
- SerpinA6 (SERPINA6 Produits)
- Synonymes
- ep45-A Protein, SERPINA6 Protein, AI265318 Protein, AV104445 Protein, Cbg Protein, CBG Protein, serpin family A member 6 Protein, serpin family A member 6 L homeolog Protein, corticosteroid-binding globulin Protein, serine (or cysteine) peptidase inhibitor, clade A, member 6 Protein, SERPINA6 Protein, serpina6.L Protein, LOC490838 Protein, Serpina6 Protein
- Sujet
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Abbreviation: SerpinA6,CBG
Target Synonym: Corticosteroid-Binding Globulin,CBG,Serpin A6,Transcortin,SERPINA6,CBG
Background: Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90 % of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
- Poids moléculaire
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Calculated MW: 44.44 kDa
Observed MW: 60 kDa
- UniProt
- P08185
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