APOH Protein (AA 1-345) (His tag)
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- Antigène Voir toutes APOH Protéines
- APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 1-345
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette APOH protéine est marqué à la His tag.
- Séquence
- Met 1-Cys 345
- Attributs du produit
- A DNA sequence encoding the Human ApoH protein (P02749) (Met 1-Cys 345) was expressed with a C-His.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product APOH Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))
- Autre désignation
- ApoH (APOH Produits)
- Synonymes
- B2G1 Protein, B2GP1 Protein, BG Protein, BETA2 Protein, BHF-1 Protein, MODY6 Protein, NEUROD Protein, bHLHa3 Protein, apoh Protein, APOH Protein, B2GPI Protein, beta-2-GPI Protein, beta2-GPI Protein, LOC100227913 Protein, apolipoprotein H Protein, neuronal differentiation 1 Protein, APOH Protein, NEUROD1 Protein, apoh Protein, Apoh Protein
- Sujet
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Abbreviation: ApoH
Target Synonym: Beta-2-Glycoprotein 1,APC inhibitor,Activated Protein C-Binding Protein,Anticardiolipin Cofactor,Apolipoprotein H,Apo-H,Beta-2-Glycoprotein I,B2GPIBeta(2)GPI,APOH,B2G1,B2GP1,BG
Background: Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. It is an essential cofactor for the binding of certain antiphospholipid antibodies (APA) to anionic phospholipid. APOH binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. APOH may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. The activity of APOH appears to involve the binding of agglutenating, negatively charged compounds, and inhibits agglutenation by the contact activation of the intrinsic blood coagulation pathway. APOH causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen when thrombin is present at physiological serum concentrations of APOH suggesting a regulatory role of APOH in coagulation. APOH plasma concentrations are strongly associated to metabolic syndrome alterations and vascular disease in type 2 diabetic and could be considered as a clinical marker of cardiovascular risk. APOH is found on several classes of lipoproteins, and is involved in the activation of lipoprotein lipase in lipid metabolism. This single-chain glycoprotein also has been implicated in several physiologic pathways including coagulation and the production of hypertension, which are related to the pathogenesis of primary cerebral hemorrhage (PICH).
- Poids moléculaire
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Calculated MW: 37.84 kDa
Observed MW: 60 kDa
- UniProt
- P02749
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