COL4A1 Protein (AA 1441-1669) (His tag)

N° du produit ABIN7505756

Détail du produit

Antigène: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Type de proteíne: Recombinant

Attributs du protein: AA 1441-1669

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette COL4A1 protéine est marqué à la His tag.

Séquence: Ser1441-Thr1669

Attributs du produit: A DNA sequence encoding the Mouse COL4 protein (P02463) (Ser1441-Thr1669) was expressed with a C-His.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Autre désignation: COL4A1 (COL4A1 Produits)

Synonymes: col4a1 Protein, wu:fc02g11 Protein, HANAC Protein, ICH Protein, POREN1 Protein, arresten Protein, Bru Protein, Col4a-1 Protein, Del(8)44H Protein, Raw Protein, Svc Protein, collagen, type IV, alpha 5 (Alport syndrome) Protein, collagen type IV alpha 1 chain Protein, collagen, type IV, alpha 1 Protein, col4a5 Protein, COL4A1 Protein, Col4a1 Protein

Sujet:

Abbreviation: COL4

Target Synonym: Collagen alpha-1(IV) chain,Arresten,Col4a1

Background: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Poids moléculaire:

Calculated MW: 25.08 kDa

Observed MW: 30 kDa

UniProt: P02463

Pathways: Skeletal Muscle Fiber Development, Growth Factor Binding