CD166 Protein (AA 1-527) (His tag)

N° du produit ABIN7505759

Détail du produit

Antigène: CD166 (ALCAM) (Activated Leukocyte Cell Adhesion Molecule (ALCAM))

Type de proteíne: Recombinant

Attributs du protein: AA 1-527

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette CD166 protéine est marqué à la His tag.

Séquence: Met1-Lys527

Attributs du produit: A DNA sequence encoding the Mouse Alcam protein (Q61490) (Met1-Lys527) was expressed with a C-His .

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CD166 (ALCAM) (Activated Leukocyte Cell Adhesion Molecule (ALCAM))

Autre désignation: ALCAM (ALCAM Produits)

Synonymes: CD166 Protein, MEMD Protein, ALCAM Protein, BEN Protein, DM-GRASP Protein, JC7 Protein, SC1 Protein, AI853494 Protein, MuSC Protein, alcam Protein, cd166 Protein, memd Protein, fb53h09 Protein, fb80a10 Protein, nlcam Protein, si:ch211-190h2.4 Protein, wu:fb53h09 Protein, wu:fb80a10 Protein, wu:fc14b01 Protein, activated leukocyte cell adhesion molecule Protein, activated leukocyte cell adhesion molecule a Protein, activated leukocyte cell adhesion molecule L homeolog Protein, CD166 antigen homolog Protein, activated leukocyte cell adhesion molecule b Protein, ALCAM Protein, Alcam Protein, alcama Protein, alcam.L Protein, alcam Protein, cd166 Protein, alcamb Protein

Sujet:

Abbreviation: ALCAM,CD166

Target Synonym: AI853494,BEN,CD166,DM-GRASP,MuSC,SC1,CD166 antigen,cluster of differentiation 166,CD166,activated leucocyte cell adhesion molecule,CD6 ligand,Protein DM-GRASP,CD6L,MEMD

Background: Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ALCAM interacts with high affinity with CD6 Molecule but weaker homotypic (ALCAM-ALCAM) interactions have also been described. ALCAM-CD6 interactions play an important role in the maintenance of T cell activation, proliferation as well as in formation of immune synapse between antigen-presenting cell and lymphocytes. ALCAM is expressed on a wide variety of cells, particularly on activated lymphocytes, dendritic cells and monocytes, and on various epithelial cell types. It is also involved in multiple processes including embryogenesis, hematopoiesis, angiogenesis, and immune response. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells in most adult tissues. Recently studies showed ALCAM has prognostic relevance in several human carcinomas, and it has been used as a biomarker for several tumor entities, including melanoma, gynecologic, urologic, and gastrointestinal cancers.

Poids moléculaire:

Calculated MW: 57.86 kDa

Observed MW: 75 kDa

UniProt: Q61490