RAGE Protein (AA 1-341) (His tag)
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- Antigène Voir toutes RAGE (AGER) Protéines
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 1-341
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Origine
- Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette RAGE protéine est marqué à la His tag.
- Séquence
- Met1-Leu341
- Attributs du produit
- A DNA sequence encoding theRat Ager protein (Q63495) (Met1-Leu341) was expressed with a C-His.
- Pureté
- > 90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product AGER Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- Autre désignation
- Ager (AGER Produits)
- Synonymes
- RAGE Protein, AGER Protein, advanced glycosylation end-product specific receptor Protein, advanced glycosylation end product-specific receptor Protein, MAPK/MAK/MRK overlapping kinase Protein, AGER Protein, Ager Protein, LOC719012 Protein
- Sujet
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Abbreviation: Ager
Target Synonym: Receptor for advanced glycosylation end products,RAGE
Background: Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.
- Poids moléculaire
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Calculated MW: 36.1 kDa
Observed MW: 45 kDa
- UniProt
- Q63495
- Pathways
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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