MMP2 Protein (AA 1-662) (His tag)

N° du produit ABIN7505797

Détail du produit

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Type de proteíne: Recombinant

Attributs du protein: AA 1-662

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette MMP2 protéine est marqué à la His tag.

Séquence: Met1-Cys662

Attributs du produit: A DNA sequence encoding the Rat Mmp2 protein (P33436) (Met1-Cys662) was expressed with a C-His.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Autre désignation: MMP2 (MMP2 Produits)

Synonymes: 2-MMP Protein, CG1794 Protein, DM2-MMP Protein, Dm2-MMP Protein, Dmel\\CG1794 Protein, MMP2 Protein, anon-WO0118547.84 Protein, dm-2MMP Protein, dmmp2 Protein, l(2)02353 Protein, mmp2 Protein, wu:fa99h12 Protein, wu:fk89d01 Protein, fgmmp-2 Protein, Mmp-2 Protein, LOC100135793 Protein, Clg4a Protein, GelA Protein, MMP-2 Protein, CLG4 Protein, CLG4A Protein, MMP-II Protein, MONA Protein, TBE-1 Protein, matrix metallopeptidase 2 Protein, Matrix metalloproteinase 2 Protein, matrix metalloproteinase 2 Protein, matrix metalloproteinase-2 Protein, MMP2 Protein, Mmp2 Protein, mmp2 Protein, LOC657982 Protein, LOC100135793 Protein

Sujet:

Abbreviation: MMP2

Target Synonym: 72 kDa type IV collagenase,EC 3.4.24.24,72 kDa gelatinase,Gelatinase A,Matrix metalloproteinase-2,MMP-2

Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels.

Poids moléculaire:

Calculated MW: 72.71 kDa

Observed MW: 72 kDa

UniProt: P33436

Pathways: Activation of Innate immune Response