CD69 Protein (CD69) (His tag)

N° du produit ABIN7519805

Détail du produit

Antigène: CD69

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette CD69 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CD69 Protein

Séquence: NVGKYNCPGL YEKLESSDHH VATCKNEWIS YKRTCYFFST TTKSWALAQR SCSEDAATLA VIDSEKDMTF LKRYSGELEH WIGLKNEANQ TWKWANGKEF NSWFNLTGSG RCVSVNHKNV TAVDCEANFH WVCSKPSR

Specificité: Asn62-Arg199

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <0.1EU/μg

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: CD69

Autre désignation: CD69 (CD69 Produits)

Synonymes: 5830438K24Rik Protein, AI452015 Protein, AIM Protein, VEA Protein, BL-AC/P26 Protein, CLEC2C Protein, EA1 Protein, GP32/28 Protein, MLR-3 Protein, Cd69 molecule Protein, CD69 antigen Protein, CD69 molecule Protein, Cd69 Protein, CD69 Protein

Sujet:

Description: Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

Name: AIM Protein,Human,BL-AC/P26 Protein,Human,CLEC2C Protein,Human,EA1 Protein,Human,GP32/28 Protein,Human,MLR-3 Protein,Human,CD69

ID gène: 12515

UniProt: P37217