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DDR2 Protein (His tag)

DDR2 Origine: Humain Hôte: HEK-293 Cells Recombinant > 97 % by SDS-PAGE. Active
N° du produit ABIN7533988
  • Antigène Voir toutes DDR2 Protéines
    DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 14
    • 6
    • 2
    Humain
    Source
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette DDR2 protéine est marqué à la His tag.
    Fonction
    Active Recombinant Human DDR2/CD167b Protein
    Séquence
    QVNPAICRYP LGMSGGQIPD EDITASSQWS ESTAAKYGRL DSEEGDGAWC PEIPVEPDDL KEFLQIDLHT LHFITLVGTQ GRHAGGHGIE FAPMYKINYS RDGTRWISWR NRHGKQVLDG NSNPYDIFLK DLEPPIVARF VRFIPVTDHS MNVCMRVELY GCVWLDGLVS YNAPAGQQFV LPGGSIIYLN DSVYDGAVGY SMTEGLGQLT DGVSGLDDFT QTHEYHVWPG YDYVGWRNES ATNGYIEIMF EFDRIRNFTT MKVHCNNMFA KGVKIFKEVQ CYFRSEASEW EPNAISFPLV LDDVNPSARF VTVPLHHRMA SAIKCQYHFA DTWMMFSEIT FQSDAAMYNN SEALPTSPMA PTTYDPMLKV DDSNTR
    Specificité
    Gln24-Arg399
    Pureté
    > 97 % by SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    < 0.1 EU/μg of the protein by LAL method.
    Biological Activity Comment
    Measured by its binding ability in a functional ELISA. Immobilized Human DDR2 Protein at 1 μg/mL (100 μL/well) can bind DDR2 Rabbit mAb with a linear range of 0.486-33.97 ng/mL.
    Top Product
    Discover our top product DDR2 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
    Buffer
    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Store the lyophilized protein at -20°C to -80 °C for long term.
    After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
  • Antigène
    DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
    Autre désignation
    DDR2/CD167b (DDR2 Produits)
    Synonymes
    MIG20a Protein, NTRKR3 Protein, TKT Protein, TYRO10 Protein, AW495251 Protein, Ntrkr3 Protein, tyro10 Protein, DDR2 Protein, Tyro10 Protein, ddr2 Protein, si:ch211-193c2.1 Protein, discoidin domain receptor tyrosine kinase 2 Protein, discoidin domain receptor family, member 2 Protein, discoidin domain receptor family, member 2, like Protein, DDR2 Protein, Ddr2 Protein, ddr2l Protein
    Sujet

    Description: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

    Name: DDR2,MIG20a,NTRKR3,TKT,TYRO10, NTRKR3, TKT, TYRO10

    ID gène
    4921
    UniProt
    Q16832
    Pathways
    Signalisation RTK
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