IL17RA Protein (His tag)

N° du produit ABIN7534426

Détail du produit

Antigène: IL17RA (Interleukin 17 Receptor A (IL17RA))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IL17RA protéine est marqué à la His tag.

Fonction: Active Recombinant Human IL-17RA/CD217 Protein

Séquence: LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPLW

Specificité: Leu33-Trp320

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: 1.Measured by its ability to inhibit IL-17A induced IL-6 secretion by Hela cells. The ED₅₀ for this effect is 0.02 0.1 μg/mL in the presence of 10 ng/mL recombinant human IL 17A.|2.Measured by its binding ability in a functional ELISA. Immobilized Recombinant human IL17RA , His Tag at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A,His Tag with a linear range of 31.25-65 ng/mL.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Détail du antigène

Antigène: IL17RA (Interleukin 17 Receptor A (IL17RA))

Autre désignation: IL-17RA/CD217 (IL17RA Produits)

Synonymes: IL17R Protein, CANDF5 Protein, CD217 Protein, CDw217 Protein, IL-17RA Protein, hIL-17R Protein, Il17r Protein, AW538159 Protein, Cdw217 Protein, VDw217 Protein, interleukin 17 receptor A Protein, IL17RA Protein, Il17ra Protein

Sujet:

Description: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. This transmembrane protein (interleukin 17A receptor, IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.

Name: CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R,IL17RA,CD217,CDw217,IL-17RA,IL17R,IMD51,hIL-17R

ID gène: 23765

UniProt: Q96F46

Pathways: SARS-CoV-2 Protein Interactome