IL2RG Protein (Fc Tag,AVI tag)
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- Antigène Voir toutes IL2RG Protéines
- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
- Type de proteíne
- Recombinant
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Origine
- Cynomolgus
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette IL2RG protéine est marqué à la Fc Tag,AVI tag.
- Fonction
- Recombinant Cynomolgus IL-2RG/CD132 Protein
- Séquence
- LNTTILTPNG NEDATTDFFL TSMPTDSLSV STLPLPEVQC FVFNVEYMNC TWNSSSEPQP TNLTLHYWYK NSDNDKVQKC SHYLFSEEIT SGCQLQEKEI HLYQTFVVQL QDPREPRRQA TQMLKLQNLV IPWAPENLTL RKLSESQLEL NWNNRFLNHC LEHLVQYRTD WDHSWTEQSV DYRHKFSLPS VDGQKRYTFR VRSRFNPLCG SAQHWSEWSH PIHWGSNSSK EN
- Specificité
- Leu23-Asn254
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- < 0.1 EU/μg of the protein by LAL method.
- Top Product
- Discover our top product IL2RG Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- Antigène
- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
- Autre désignation
- IL-2RG/CD132 (IL2RG Produits)
- Synonymes
- Ab2-183 Protein, Cd132 Protein, CD132 Protein, CIDX Protein, IL-2RG Protein, IMD4 Protein, P64 Protein, SCIDX Protein, SCIDX1 Protein, [g]c Protein, gamma(c) Protein, gc Protein, interleukin 2 receptor subunit gamma Protein, interleukin 2 receptor subunit gamma L homeolog Protein, interleukin 2 receptor, gamma chain Protein, IL2RG Protein, il2rg.L Protein, Il2rg Protein
- Sujet
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Description: The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.
Name: IL2RG,CD132,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC,IL2RG
- ID gène
- 641338
- UniProt
- Q38JL2
- Pathways
- Signalistation JAK/STAT, Growth Factor Binding
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