CDH6 Protein (His tag)

N° du produit ABIN7534352

Détail du produit

Antigène: CDH6 (K-Cadherin (CDH6))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CDH6 protéine est marqué à la His tag.

Fonction: Active Recombinant Human CDH6/K-Cadherin Protein

Séquence: TLSTPLSKRT SGFPAKKRAL ELSGNSKNEL NRSKRSWMWN QFFLLEEYTG SDYQYVGKLH SDQDRGDGSL KYILSGDGAG DLFIINENTG DIQATKRLDR EEKPVYILRA QAINRRTGRP VEPESEFIIK IHDINDNEPI FTKEVYTATV PEMSDVGTFV VQVTATDADD PTYGNSAKVV YSILQGQPYF SVESETGIIK TALLNMDREN REQYQVVIQA KDMGGQMGGL SGTTTVNITL TDVNDNPPRF PQSTYQFKTP ESSPPGTPIG RIKASDADVG ENAEIEYSIT DGEGLDMFDV ITDQETQEGI ITVKKLLDFE KKKVYTLKVE ASNPYVEPRF LYLGPFKDSA TVRIVVEDVD EPPVFSKLAY ILQIREDAQI NTTIGSVTAQ DPDAARNPVK YSVDRHTDMD RIFNIDSGNG SIFTSKLLDR ETLLWHNITV IATEINNPKQ SSRVPLYIKV LDVNDNAPEF AEFYETFVCE KAKADQLIQT LHAVDKDDPY SGHQFSFSLA PEAASGSNFT IQDNKDNTAG ILTRKNGYNR HEMSTYLLPV VISDNDYPVQ SSTGTVTVRV CACDHHGNMQ SCHAEALIHP TGLSTGA

Specificité: Thr19-Ala615

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized Human CDH6 at 1μg/mL (100 μL/well) can bind CDH6 Mouse mAb with a linear range of 0.05-6.31 ng/mL.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Détail du antigène

Antigène: CDH6 (K-Cadherin (CDH6))

Autre désignation: CDH6/K-Cadherin (CDH6 Produits)

Synonymes: KCAD Protein, K-cadherin Protein, cad6 Protein, cadherin-6 Protein, CAD6 Protein, c-cad6B Protein, cadherin 6 Protein, Cdh6 Protein, CDH6 Protein

Sujet:

Description: CDH6 is a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus , Cadherin-6 is a new prognostic factor for renal cancer.

Name: CAD6, KCAD,CDH6,KCAD

ID gène: 1004

UniProt: P55285-1

Pathways: Cell-Cell Junction Organization