P-Cadherin Protein (CDH3) (His tag)

N° du produit ABIN7520380

Détail du produit

Antigène: P-Cadherin (CDH3)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette P-Cadherin protéine est marqué à la His tag.

Fonction: Active Recombinant Human CDH3/P-cadherin Protein

Séquence: DWVVAPISVP ENGKGPFPQR LNQLKSNKDR DTKIFYSITG PGADSPPEGV FAVEKETGWL LLNKPLDREE IAKYELFGHA VSENGASVED PMNISIIVTD QNDHKPKFTQ DTFRGSVLEG VLPGTSVMQV TATDEDDAIY TYNGVVAYSI HSQEPKDPHD LMFTIHRSTG TISVISSGLD REKVPEYTLT IQATDMDGDG STTTAVAVVE ILDANDNAPM FDPQKYEAHV PENAVGHEVQ RLTVTDLDAP NSPAWRATYL IMGGDDGDHF TITTHPESNQ GILTTRKGLD FEAKNQHTLY VEVTNEAPFV LKLPTSTATI VVHVEDVNEA PVFVPPSKVV EVQEGIPTGE PVCVYTAEDP DKENQKISYR ILRDPAGWLA MDPDSGQVTA VGTLDREDEQ FVRNNIYEVM VLAMDNGSPP TTGTGTLLLT LIDVNDHGPV PEPRQITICN QSPVRQVLNI TDKDLSPHTS PFQAQLTDDS DIYWTAEVNE EGDTVVLSLK KFLKQDTYDV HLSLSDHGNK EQLTVIRATV CDCHGHVETC PGPWKGG

Specificité: Asp108-Gly654

Pureté: > 85 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <1EU/μg

Biological Activity Comment: Measured by the ability of the immobilized protein to support the adhesion of A431 human epithelial carcinoma cells. When 1x105 cells/well are added to rhP-CAD/Fc Chimera coated plates (10 μg/mL with 100 μL/well), approximately 50-60% will adhere after 1.5 hours at 37° C.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: P-Cadherin (CDH3)

Autre désignation: CDH3/P-cadherin (CDH3 Produits)

Synonymes: CDH3 Protein, Cadherin-3 Protein, AI385538 Protein, Cadp Protein, Cdhp Protein, P-cadherin Protein, Pcad Protein, CDHP Protein, HJMD Protein, PCAD Protein, E-Cad Protein, E-cadherin Protein, EP-cadherin Protein, XTCAD-1 Protein, c-cadherin Protein, cadherin-1 Protein, cdh1 Protein, cdh1-b Protein, cdh3 Protein, cdhc-A Protein, cdhp Protein, hjmd Protein, l-cam Protein, lcam Protein, pcad Protein, uvo Protein, uvomorulin Protein, xb-cad Protein, xcdh1 Protein, CDH15 Protein, K-CAM Protein, cadherin 3 Protein, cadherin 3 L homeolog Protein, Cadherin-3 Protein, CDH3 Protein, Cdh3 Protein, cdh3.L Protein, cdh-3 Protein

Sujet:

Description: Cadherin-3 (also known as P-cadherin)is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. In humans, cadherin-3 is only detected in a few organs. However, its overexpression is strongly associated with a poor prognosis in some solid tumors including breast, lung and pancreatic cancers.

Name: CDH3,CDHP,HJMD,PCAD

ID gène: 1001

UniProt: P22223