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CASR Protéine

CASR Origine: Humain Hôte: Mammalian Cells Synthetic Nanodisc
N° du produit ABIN7538156
  • Antigène Voir toutes CASR Protéines
    CASR (Calcium-Sensing Receptor (CASR))
    Type de proteíne
    Synthetic Nanodisc
    Origine
    • 7
    • 2
    • 1
    Humain
    Source
    • 4
    • 3
    • 1
    Mammalian Cells
    Fonction
    Human CASR full length protein-synthetic nanodisc
    Attributs du produit
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product CASR Protéine
  • Commentaires

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Date de péremption
    12 months
  • Antigène
    CASR (Calcium-Sensing Receptor (CASR))
    Autre désignation
    CASR (CASR Produits)
    Synonymes
    CAR Protein, EIG8 Protein, FHH Protein, FIH Protein, GPRC2A Protein, HHC Protein, HHC1 Protein, HYPOC1 Protein, NSHPT Protein, PCAR1 Protein, CaR Protein, Gprc2a Protein, gprc2a Protein, xV2R F-1 Protein, CASR Protein, calcium sensing receptor Protein, calcium-sensing receptor Protein, calcium-sensing receptor L homeolog Protein, CASR Protein, Casr Protein, casr.L Protein
    Sujet
    The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
    Poids moléculaire
    The human full length CASR protein has a MW of 120.7kDa
    UniProt
    P41180
    Pathways
    Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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