CRLF2 Protein (AA 23-231) (His tag)
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- Antigène Voir toutes CRLF2 Protéines
- CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 23-231
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Origine
- Humain
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Source
- Mammalian Cells
- Purification/Conjugué
- Cette CRLF2 protéine est marqué à la His tag.
- Fonction
- Recombinant Human CRLF2 Protein with C-terminal 6XHis tag
- Specificité
- CRLF2 (Gln23-Lys231) 6xHis tag
- Attributs du produit
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Pureté
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product CRLF2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Date de péremption
- 12 months
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- Antigène
- CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))
- Autre désignation
- CRLF2 (CRLF2 Produits)
- Synonymes
- CRLF2 Protein, CRL2 Protein, CRLF2Y Protein, TSLPR Protein, CRLM2 Protein, Ly114 Protein, Tpte2 Protein, Tslpr Protein, Crl2 Protein, cytokine receptor like factor 2 Protein, cytokine receptor-like factor 2 Protein, CRLF2 Protein, Crlf2 Protein
- Sujet
- This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
- Poids moléculaire
- predicted molecular mass of 25.0 kDa after removal of the signal peptide. The apparent molecular mass of CRLF2-His is 25-55 kDa due to glycosylation.
- UniProt
- Q9HC73
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