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FZD6 Protéine

FZD6 Origine: Humain Hôte: Mammalian Cells Synthetic Nanodisc
N° du produit ABIN7538248
  • Antigène Voir toutes FZD6 Protéines
    FZD6 (Frizzled Family Receptor 6 (FZD6))
    Type de proteíne
    Synthetic Nanodisc
    Origine
    Humain
    Source
    • 1
    • 1
    • 1
    Mammalian Cells
    Fonction
    Human FZD6 full length protein-synthetic nanodisc
    Attributs du produit
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product FZD6 Protéine
  • Commentaires

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Date de péremption
    12 months
  • Antigène
    FZD6 (Frizzled Family Receptor 6 (FZD6))
    Autre désignation
    FZD6 (FZD6 Produits)
    Synonymes
    zgc:65879 Protein, zgc:77440 Protein, fz6 Protein, frz6 Protein, Xfrz6 Protein, frizzled6 Protein, frizzled-6 Protein, FZ-6 Protein, FZ6 Protein, HFZ6 Protein, NDNC10 Protein, Frizzled-6 Protein, Fz6 Protein, frizzled class receptor 6 Protein, frizzled class receptor 6 S homeolog Protein, fzd6 Protein, fzd6.S Protein, FZD6 Protein, Fzd6 Protein
    Sujet
    This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
    Poids moléculaire
    The human full length FZD6 protein has a MW of 79.3kDa
    UniProt
    O60353
    Pathways
    Signalisation WNT, Tube Formation
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