Integrin beta 4 Protein (ITGB4)
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- Antigène Voir toutes Integrin beta 4 (ITGB4) Protéines
- Integrin beta 4 (ITGB4)
- Type de proteíne
- Synthetic Nanodisc
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Origine
- Humain
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Source
- Mammalian Cells
- Fonction
- Human GP150 full length protein-synthetic nanodisc
- Attributs du produit
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product ITGB4 Protéine
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- Commentaires
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Date de péremption
- 12 months
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- Antigène
- Integrin beta 4 (ITGB4)
- Autre désignation
- GP150 (ITGB4 Produits)
- Synonymes
- AA407042 Protein, C230078O20 Protein, CD104 Protein, integrin subunit beta 4 Protein, integrin beta 4 Protein, ITGB4 Protein, Itgb4 Protein
- Sujet
- This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the vasopressin-like subfamily that also includes vasopressin and oxytocin receptors. The silencing of this gene, due to promoter methylation, is associated with ovarian cancer progression. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
- Poids moléculaire
- The human full length GP150 protein has a MW of 46.4kDa
- UniProt
- Q8NGU9
- Pathways
- Integrin Complex
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