IFNA2 Protein (AA 24-188) (Fc Tag)

N° du produit ABIN7538336

Détail du produit

Antigène: IFNA2 (Interferon, alpha 2 (IFNA2))

Type de proteíne: Recombinant

Attributs du protein: AA 24-188

Origine: Humain

Source: Mammalian Cells

Purification/Conjugué: Cette IFNA2 protéine est marqué à la Fc Tag.

Fonction: Recombinant human IFNA2 Protein with C-terminal human Fc tag

Specificité: IFNA2 (Cys24-Glu188) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: IFNA2 (Interferon, alpha 2 (IFNA2))

Autre désignation: IFNA2 (IFNA2 Produits)

Synonymes: IFN-alphaA Protein, IFNA Protein, IFNA2B Protein, INFA2 Protein, Ifa2 Protein, IFNA2 Protein, interferon alpha 2 Protein, interferon, alpha 2 Protein, interferon-alpha-2 Protein, interferon alpha-2 Protein, IFNA2 Protein, Ifna2 Protein, ifna2 Protein, IFN-ALPHA2 Protein, LOC102142148 Protein

Sujet: This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. [provided by RefSeq, Aug 2020]

Poids moléculaire: predicted molecular mass of 45.4 kDa after removal of the signal peptide. The apparent molecular mass of IFNA2-hFc is 55-70 kDa due to glycosylation.

UniProt: P01563

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Hepatitis C