Macrophage Scavenger Receptor 1 Protein (MSR1) (AA 77-451) (His tag)
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- Antigène Voir toutes Macrophage Scavenger Receptor 1 (MSR1) Protéines
- Macrophage Scavenger Receptor 1 (MSR1)
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 77-451
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Origine
- Humain
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Source
- Mammalian Cells
- Purification/Conjugué
- Cette Macrophage Scavenger Receptor 1 protéine est marqué à la His tag.
- Fonction
- Recombinant human MSR1 Protein with N-terminal 6xHis tag
- Specificité
- 6xHis tag MSR1 (Lys77-Leu451)
- Attributs du produit
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Pureté
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product MSR1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Date de péremption
- 12 months
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- Antigène
- Macrophage Scavenger Receptor 1 (MSR1)
- Autre désignation
- MSR1 (MSR1 Produits)
- Synonymes
- CD204 Protein, SCARA1 Protein, SR-A Protein, SRA Protein, phSR1 Protein, phSR2 Protein, MRS-A Protein, MSR Protein, MSR-A Protein, SR-AI Protein, SR-AII Protein, Scara1 Protein, Scvr Protein, MSR1 Protein, RGD1564316 Protein, macrophage scavenger receptor 1 Protein, scavenger receptor class A member 5 Protein, MSR1 Protein, Msr1 Protein, SCARA5 Protein
- Sujet
- This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
- Poids moléculaire
- predicted molecular mass of 42.1 kDa after removal of the signal peptide.
- UniProt
- P21757
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