PLA2R1 Protéine

N° du produit ABIN7538475

Détail du produit

Antigène: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Type de proteíne: Synthetic Nanodisc

Origine: Humain

Source: Mammalian Cells

Fonction: Human PLA2R1 full length protein-synthetic nanodisc

Attributs du produit: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Information d'application

Commentaires:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Autre désignation: PLA2R1 (PLA2R1 Produits)

Synonymes: Pla2-r Protein, Pla2g1br Protein, Pla2r Protein, CLEC13C Protein, PLA2-R Protein, PLA2G1R Protein, PLA2IR Protein, PLA2R Protein, phospholipase A2 receptor 1 Protein, PLA2R1 Protein, Pla2r1 Protein

Sujet: This protein is a phospholipase A2 receptor. The protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: The human full length PLA2R1 protein has a MW of 168.6 kDa

UniProt: Q13018

Pathways: Positive Regulation of Response to DNA Damage Stimulus