5HT1D Protéine

N° du produit ABIN7538520

Détail du produit

Antigène: 5HT1D (HTR1D) (Serotonin Receptor 1D (HTR1D))

Type de proteíne: Synthetic Nanodisc

Origine: Humain

Source: Mammalian Cells

Fonction: Human 5HT1D full length protein-synthetic nanodisc

Attributs du produit: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Information d'application

Commentaires:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: 5HT1D (HTR1D) (Serotonin Receptor 1D (HTR1D))

Autre désignation: 5HT1D (HTR1D Produits)

Synonymes: AI853647 Protein, Gpcr14 Protein, Htr1db Protein, 5-HT1D Protein, HT1DA Protein, HTR1DA Protein, HTRL Protein, RDC4 Protein, 5HT1D Protein, 5-HT-1D Protein, 5-hydroxytryptamine (serotonin) receptor 1D Protein, 5-hydroxytryptamine receptor 1D Protein, Htr1d Protein, HTR1D Protein

Sujet: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.[UniProtKB/Swiss-Prot Function]

Poids moléculaire: The human full length 5HT1D protein has a MW of 41.9kDa

UniProt: P28221

Pathways: Signalistation JAK/STAT