DKK2 Protein (His tag)

N° du produit ABIN7539309

Détail du produit

Antigène: DKK2 (Dickkopf 2 Homolog (DKK2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette DKK2 protéine est marqué à la His tag.

Fonction: Dkk-2

Séquence: MKLNSIKSSL GGETPGQAAN RSAGMYQGLA FGGSKKGKNL GQAYPCSSDK ECEVGRYCHS PHQGSSACMV CRRKKKRCHR DGMCCPSTRC NNGICIPVTE SILTPHIPAL DGTRHRDRNH GHYSNHDLGW QNLGRPHTKM SHIKGHEGDP CLRSSDCIEG FCCARHFWTK ICKPVLHQGE VCTKQRKKGS HGLEIFQRCD CAKGLSCKVW KDATYSSKAR LHVCQKITRL EHHHHHH

Specificité: Chromosomal location:10q11.2

Attributs du produit: Length (aa):235

Pureté: 95 % by SDS-PAGE and visualized Coomassie stain

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: water

Buffer: PBS

Détail du antigène

Antigène: DKK2 (Dickkopf 2 Homolog (DKK2))

Autre désignation: Dkk-2 (DKK2 Produits)

Synonymes: DKK-2 Protein, Dkk4 Protein, zgc:171574 Protein, dickkopf WNT signaling pathway inhibitor 2 Protein, DKK2 Protein, Dkk2 Protein, dkk2 Protein

Sujet: Dickkopf-related protein-2, Dickkopf-2,The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling, enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Poids moléculaire: 26.0 kDa

ID gène: 22943

NCBI Accession: NM_012242, NP_036374

UniProt: O94907

Pathways: Signalisation WNT