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Endothelin 1 Protein (EDN1) (His tag)

EDN1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 98 % by SDS-PAGE and visualized Coomassie stain
N° du produit ABIN7539311
  • Antigène Voir toutes Endothelin 1 (EDN1) Protéines
    Endothelin 1 (EDN1)
    Type de proteíne
    Recombinant
    Origine
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Humain
    Source
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette Endothelin 1 protéine est marqué à la His tag.
    Fonction
    Endothelin-1/ET-1
    Séquence
    MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH
    Attributs du produit
    Length (aa):204
    Pureté
    > 98 % by SDS-PAGE and visualized Coomassie stain
    Top Product
    Discover our top product EDN1 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    water
    Buffer
    PBS
  • Antigène
    Endothelin 1 (EDN1)
    Autre désignation
    Endothelin-1/ET-1 (EDN1 Produits)
    Synonymes
    et1 Protein, et-1 Protein, Edn1 Protein, EDN Protein, ET-1 Protein, ET1 Protein, PPET1 Protein, HDLCQ7 Protein, preproET Protein, Et1 Protein, fb14d01 Protein, wu:fb14d01 Protein, PPET-1 Protein, EDN1 Protein, edn1 Protein, edn1-a Protein, edn1-b Protein, endothelin 1 Protein, endothelin 1 S homeolog Protein, endothelin 1 L homeolog Protein, edn1 Protein, EDN1 Protein, Edn1 Protein, edn1.S Protein, edn1.L Protein
    Sujet
    Preproendothelin-1, PPET-1, ET-1, EDN1,Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.
    Poids moléculaire
    26.0 kDa
    ID gène
    1906
    NCBI Accession
    NM_01955, NP_001946
    UniProt
    P05305
    Pathways
    Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size
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