alpha-Thrombin Protéine

N° du produit ABIN934838

Détail du produit

Antigène: alpha-Thrombin

Type de proteíne: Native

Activité biologique: Active

Origine: Humain

Source: Human

Attributs du produit: Purified native Human alpha Thrombin protein
Bioactivity: 4493 units/mg protein- Specific activity is determined by fibrinogen clotting assay relative to human NIH standard thrombin.
Protein Source: Human serum/plasma

Pureté: > 95 % pure

Information d'application

Indications d'application: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as a liquid with 50 % Glycerol/H2 O (vol/vol).

Précaution d'utilisation: Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20 °C.

Référence

Steinert, Berg, Kalinin, Jagels, Würthwein, Humpf, Kalinina: "Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum." dans: ACS omega, Vol. 7, Issue 49, pp. 45215-45230, (2022) (PubMed).

Dunker, Imberg, Siutkina, Erbacher, Daniliuc, Karst, Kalinin: "Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity." dans: Pharmaceuticals (Basel, Switzerland), Vol. 15, Issue 11, (2022) (PubMed).

Platte, Korff, Imberg, Balicioglu, Erbacher, Will, Daniliuc, Karst, Kalinin: "Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors." dans: ChemMedChem, Vol. 16, Issue 24, pp. 3672-3690, (2022) (PubMed).

Détail du antigène

Antigène: alpha-Thrombin

Autre désignation: alpha Thrombin (alpha-Thrombin Produits)

Synonymes: PT Protein, RPRGL2 Protein, THPH1 Protein, coagulation factor II, thrombin Protein, F2 Protein

Sujet: Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII.
Description: Human serum/plasma.
Alternative Names: Thrombin alpha protein

Poids moléculaire: 36.7 kDa