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Sujet
HINT1, also known as Histidine triad nucleotide-binding protein 1, is a member of a superfamily named for a near C-terminal HXHXHXX motif (H:Histidine, X:a hydrophobic amino acid) positioned at the alpha-phosphate of nucleotide substrates. This protein hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Although it was originally thought to be a protein kinase C inhibitor and act as a haplod-insufficient tumor suppressor including spontaneous tumor formation in Hint+/- and Hint-/- , its actual physiologic function is not known. Recombinant human HINT1 protein was expressed in E. coli and purified by using conventional chromatography. Alternative Names: PKCI1 protein, HINT 1 protein, Histidine triad nucleotide binding protein 1 protein, HINT1, Histidine triad nucleotide-binding protein 1 Adenosine 5' monophosphoramidase protein, Histidine triad nucleotide-binding protein 1 protein, PKCI 1 protein, HINT 1, HINT protein, HINT-1 protein, PKCI-1 protein, Protein kinase C interacting protein 1., PRKCNH1 protein, HINT 1 protein, HINT-1, Protein kinase C inhibitor 1 protein