Purified recombinant Human BD4 protein Expression System: E.coli Bioactivity: Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-100.0 ng/mL.
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified, BD-1, BD-2, BD-3 and BD-4. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. beta-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. Alternative Names: BEFB4 protein, BD 4 protein, beta-defensin 104 protein, BD 4 protein, BD-4, BD-4 protein, BD 4, BD4, BD-4 protein