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CD14 Protein (CD14) (Soluble)

CD14 Origine: Humain Hôte: HEK-293T Cells Recombinant > 95 % pure Active
N° du produit ABIN935793
  • Antigène Voir toutes CD14 Protéines
    CD14
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    Soluble
    Origine
    • 21
    • 5
    • 4
    • 1
    • 1
    • 1
    Humain
    Source
    • 16
    • 10
    • 2
    • 2
    • 1
    • 1
    HEK-293T Cells
    Séquence
    TTPEPCELDD EDFRCVCNFS EPQPDWSEAF QCVSAVEVEI HAGGLNLEPF LKRVDADADP RQYADTVKAL RVRRLTVGAA QVPAQLLVGA LRVLAYSRLK ELTLEDLKIT GTMPPLPLEA TGLALSSLRL RNVSWATGRS WLAELQQWLK PGLKVLSIAQ AHSPAFSCEQ VRAFPALTSL DLSDNPGLGE RGLMAALCPH KFPAIQNLAL RNTGMETPTG VCAALAAAGV QPHSLDLSHN SLRATVNPSA PRCMWSSALN SLNLSFAGLE QVPKGLPAKL RVLDLSCNRL NRAPQPDELP EVDNLTLDGN PFLVPGTALP HEGSMNSGVV P
    Attributs du produit
    Purified recombinant Human sCD14 protein
    Expression System: 293 cells
    Bioactivity: Determined by the dose dependent activation of NF-kappaB in a RAW264 cell line based reporter system, using a sCD14 concentration range of 20 ng/ul to 200 ng/ul. The NF-kappaB activation is enhanced when the assay is done in the presence of 0.25 ng/ul to 1.0 ng/ul bacterial LPS.
    Pureté
    > 95 % pure
    niveau d'endotoxine
    < 0.1 ng per µg (1 EU/µg).
    Top Product
    Discover our top product CD14 Protéine
  • Indications d'application
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Supplied as a lyophilized powder.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
  • Antigène
    CD14
    Autre désignation
    sCD14 (CD14 Produits)
    Synonymes
    CD14 molecule Protein, CD14 antigen Protein, CD14 Protein, Cd14 Protein
    Sujet
    CD14 is a cell surface anchored glycoprotein that is expressed predominantly by monocytes and tissue macrophages. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappa-beta. CD14 also exists in a soluble form, designated as sCD14, which is capable of specifically binding LPS in the extracellular space.
    Alternative Names: sCD-14 protein, sCD-14, sCD-14 protein, sCD 14 protein, sCD14, soluble CD14 protein, sCD 14
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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