CXCL5 Protein (AA 5-78)

N° du produit ABIN987804

Détail du produit

Antigène: CXCL5 (Chemokine (C-X-C Motif) Ligand 5 (CXCL5))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 5-78

Origine: Humain

Source: Escherichia coli (E. coli)

Séquence: AAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKE

Attributs du produit: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human peripheral blood neutrophils is less than 10 ng/ml, corresponding to a specific activity of >, 1.0 × 105 IU/mg.

Pureté: > 97 % by SDS-PAGE and HPLC analyses.

niveau d'endotoxine: Level Less than 1EU/µg of rHuENA-78/CXCL5 as determined by LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Stock: 4 °C

Détail du antigène

Antigène: CXCL5 (Chemokine (C-X-C Motif) Ligand 5 (CXCL5))

Autre désignation: ENA-78/CXCL5 (CXCL5 Produits)

Synonymes: ENA-78 Protein, SCYB5 Protein, Cxcl6 Protein, CXCL5 Protein, GCP-2 Protein, GCP2 Protein, SCYB6 Protein, AMCF-II Protein, LIX Protein, Scyb5 Protein, Scyb6 Protein, C-X-C motif chemokine ligand 5 Protein, C-X-C motif chemokine ligand 6 Protein, chemokine (C-X-C motif) ligand 5 Protein, C-X-C motif chemokine 5 Protein, CXCL5 Protein, Cxcl6 Protein, LOC701946 Protein, LOC703222 Protein, Cxcl5 Protein

Sujet: Epithelial cell-derived neutrophil-activating peptide 78 (ENA-78) is a member of the CXC subfamily of chemokines that has the Glu-Leu-Arg (ELR) motif preceding the CXC motif. Similar to other ELR containing CXC chemokines, ENA-78 is a potent neutrophil chemoattractant and activator. Proteolysis of ENA-78 with cathepsin G and chymotrypsin have yielded N-terminally truncated variants with increased biological activities. ENA-70 and ENA-74 represent truncated recombinant ENA-78 variants missing 8 and 4 aa residues, respectively, from the N-terminus. Recombinant ENA-70 and ENA-74 have been shown to have increased potency in neutrophil chemotaxis and myeloperoxidase and elastase release assays. Synonym: ENA-78/CXCL5 (5-78a.a.), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 50mM NaCl.

Poids moléculaire: 8.0 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity