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Exendin 4 Protéine

Origine: Gila monster Hôte: Escherichia coli (E. coli) Recombinant > 96 % by SDS-PAGE and HPLC analyses. Active
N° du produit ABIN987837
  • Antigène Tous les produits Exendin 4
    Exendin 4
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    Gila monster
    Source
    Escherichia coli (E. coli)
    Séquence
    HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPP
    Attributs du produit
    1. Regulates Glucose levels rapidly 2. Reduces Insulin resistence 3. Reduces Glucagon 4. Reduces HbA1c 5. Stimulates beta cell growth which stimulates insulin production.
    Pureté
    > 96 % by SDS-PAGE and HPLC analyses.
    niveau d'endotoxine
    Level Less than 10EU/mg of rExendin-4 as determined by LAL method
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
    Stock
    4 °C
  • Antigène
    Exendin 4
    Autre désignation
    Exendin-4 (Exendin 4 Produits)
    Sujet
    Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes ß-cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA squence encoding the 39 amino acid of Exendin-4. Synonym: Exendin-4. Formulation: Lyophilized from a 0.2um filtered solution of 20mM PBS, pH 7.0, containing 4% mannitol.
    Poids moléculaire
    Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.
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