FGF21 Protéine

N° du produit ABIN987848

Détail du produit

Antigène: FGF21 (Fibroblast Growth Factor 21 (FGF21))

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Séquence: MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSPESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELLLEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEPPGILAPQPPD VGSSDPLSMV GPSQGRSPSY A

Attributs du produit: Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using murine NIH/3T3 cells is less than 600 ng/ml, corresponding to a specific activity of >, 1.7 × 103 IU/mg in the presence of 5myg/ml of rMuKlotho-beta.

Pureté: > 95 % by SDS-PAGE and HPLC analyses.

niveau d'endotoxine: Level Less than 1EU/µg of rHuFGF-21 as determined by LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Stock: 4 °C

Détail du antigène

Antigène: FGF21 (Fibroblast Growth Factor 21 (FGF21))

Autre désignation: Fibrobalst Growth Factor-21(FGF-21) (FGF21 Produits)

Synonymes: FGF21 Protein, fibroblast growth factor 21 Protein, FGF21 Protein, fgf21 Protein, Fgf21 Protein

Sujet: Fibroblast growth factor 21 (FGF21) belongs to the large FGF family which has at least 23 members. All FGF family members are heparin binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGFs are expressed during embryonic development and in restricted adult tissues. Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes. Synonym: Fibroblast Growth Factor-21(FGF-21), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Poids moléculaire: Approximately 19.5 kDa, a single non-glycosylated polypeptide chain containing 182 amino acids.

Pathways: Signalisation RTK