CCL23 Protéine

N° du produit ABIN988165

Détail du produit

Antigène: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Séquence: RVTKDAETEF MMSKLPLENP VLLDRFHATS ADCCISYTPR SIPCSLLESY FETNSECSKP GVIFLTKKGR RFCANPSDKQ VQVCMRMLKL DTRIKTRK

Attributs du produit: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human THP-1 cells is less than 40 ng/ml, corresponding to a specific activity of >, 2.5 × 104 IU/mg.

Pureté: > 97 % by SDS-PAGE and HPLC analyses.

niveau d'endotoxine: Level Less than 1EU/µg of rHuMIP-3/CCL23 as determined by LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Stock: 4 °C

Détail du antigène

Antigène: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Autre désignation: MIP-3/CCL23 (CCL23 Produits)

Synonymes: CK-BETA-8 Protein, CKb8 Protein, Ckb-8 Protein, Ckb-8-1 Protein, MIP-3 Protein, MIP3 Protein, MPIF-1 Protein, SCYA23 Protein, hmrp-2a Protein, C-C motif chemokine 23 Protein, C-C motif chemokine ligand 23 Protein, chemokine (C-C motif) ligand 23 Protein, LOC508666 Protein, CCL23 Protein

Sujet: MIP-3/CCL23 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Alternative splicing of the MPIF1 gene results in two mRNAs that encode a short (CKbeta8) and a long (CKbeta81) isoform of the chemokine. CKbeta8 cDNA encodes a 120 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to generate a 99 aa residue mature CKbeta8 (aa 22 120). Additional N terminal processing of the 99 aa residue variant can generate a 75 aa residue CKbeta8 (aa 46 120) that is significantly more active than the 99 aa residue variant. Synonym: MIP-3/CCL23, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

Poids moléculaire: 11.3 kDa, a single, non-glycosylated polypeptide chain containing 99 amino acids.