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PSMA Produits

(Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010].

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Catégories PSMA en vedette

PSMA Anticorps

High quality antibodies with extensive validation data.

PSMA Kits ELISA

Reliable ELISA kits for a wide range of species.

PSMA Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PSMA recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Pig, Rat
Application WB, IHC (p), ICC
Validations
  • (9)
  • (8)
N° du produit ABIN1302364
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application IHC
Validations
  • (6)
N° du produit ABIN7234408
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
N° du produit ABIN7443569
Quantité 100 μL
Fiche technique Fiche technique

PSMA recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6975679
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6962642
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6951666
Quantité 96 tests
Fiche technique Fiche technique

PSMA recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7275493
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7275491
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7275488
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PSMA

Wächter, Di Fazio, Maurer, Manoharan, Keber, Pfestroff, Librizzi, Bartsch, Luster, Eilsberger: "Prostate-Specific Membrane Antigen in Anaplastic and Poorly Differentiated Thyroid Cancer-A New Diagnostic and Therapeutic Target?" dans: Cancers, Vol. 13, Issue 22, (2021) (PubMed).

Schreiber, Hänze, Nimphius, Verburg, Luster, Hofmann, Hegele: "Prostate specific membrane antigen (PSMA) in urothelial cell carcinoma (UCC) is associated with tumor grading and staging." dans: Journal of cancer research and clinical oncology, (2020) (PubMed).

Dowling, Samuelson, Fadl-Alla, Pondenis, Byrum, Barger, Fan: "Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions." dans: PLoS ONE, Vol. 14, Issue 1, pp. e0210297, (2019) (PubMed).

Gorges, Riethdorf, von Ahsen, Nastał Y, Röck, Boede, Peine, Kuske, Schmid, Kneip, König, Rudolph, Pantel: "Heterogeneous PSMA expression on circulating tumor cells: a potential basis for stratification and monitoring of PSMA-directed therapies in prostate cancer." dans: Oncotarget, Vol. 7, Issue 23, pp. 34930-41, (2018) (PubMed).

Gao, Xu, Cui, Zhang, Lin, Cai, Wang, Luo, Zheng, Wang, Luo, Jiang, Neale, Zhong: "Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury." dans: Journal of neurochemistry, Vol. 134, Issue 2, pp. 340-53, (2015) (PubMed).

Kadimisetty, Malla, Sardesai, Joshi, Faria, Lee, Rusling: "Automated multiplexed ECL Immunoarrays for cancer biomarker proteins." dans: Analytical chemistry, Vol. 87, Issue 8, pp. 4472-8, (2015) (PubMed).

Tykvart, Navrátil, Sedlák, Corey, Colombatti, Fracasso, Koukolík, Ba?inka, Sácha, Konvalinka: "Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA)." dans: The Prostate, Vol. 74, Issue 16, pp. 1674-90, (2014) (PubMed).

Liu, Lu, Zhou, Xu, Chen: "Flexible gold electrode array for multiplexed immunoelectrochemical measurement of three protein biomarkers for prostate cancer." dans: ACS applied materials & interfaces, Vol. 6, Issue 22, pp. 20137-43, (2014) (PubMed).

Walder, Ryan, Bzdega, Olszewski, Neale, Lindgren: "Immunohistological and electrophysiological evidence that N-acetylaspartylglutamate is a co-transmitter at the vertebrate neuromuscular junction." dans: The European journal of neuroscience, Vol. 37, Issue 1, pp. 118-29, (2013) (PubMed).

Hudson, Uhlen, Rockberg: "Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes." dans: Scientific reports, Vol. 2, pp. 706, (2012) (PubMed).

Synonymes et noms alternatifs relatifs à PSMA

putative N-acetylated-alpha-linked acidic dipeptidase (LOC451185), folate hydrolase 1B (FOLH1B), folate hydrolase 1 (FOLH1), folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1), folate hydrolase 1 (Folh1), FGCP, FOLH, GCP2, GCPII, mGCP, mopsm, Naalad, NAALAD1, NAALAdase, PSM, PSMA

Protein level used designations for PSMA

  • folate hydrolase 1
  • glutamate carboxypeptidase 2
  • folate hydrolase (prostate-specific membrane antigen) 1
  • glutamate carboxypeptidase 2-like
  • N-acetylated alpha-linked acidic dipeptidase 1
  • N-acetylated-alpha-linked acidic dipeptidase I
  • NAALADase I
  • cell growth-inhibiting gene 27 protein
  • folylpoly-gamma-glutamate carboxypeptidase
  • glutamate carboxylase II
  • glutamate carboxypeptidase II
  • membrane glutamate carboxypeptidase
  • prostate specific membrane antigen variant F
  • pteroylpoly-gamma-glutamate carboxypeptidase
  • FGCP
  • GCPII
  • mGCP
  • prostate-specific membrane antigen homolog
  • prostate-specific membrane antigen
  • N-acetylated alpha-linked acidic dipeptidase
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