PSMC1 Produits
(Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))
Catégories
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008].
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Catégories PSMC1 en vedette
PSMC1 Anticorps
High quality antibodies with extensive validation data.
PSMC1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PSMC1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), IF
Validations
- (3)
- (3)
N° du produit
ABIN1881692
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (3)
N° du produit
ABIN7237615
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (2)
N° du produit
ABIN7442210
Quantité
100 μL
Fiche technique
Fiche technique
PSMC1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6229234
Quantité
96 tests
Fiche technique
Fiche technique
PSMC1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7579033
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7414540
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2729955
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PSMC1
: "Global profiling of co- and post-translationally N-myristoylated proteomes in human cells." dans: Nature communications, Vol. 5, pp. 4919, (2014) (PubMed).: "A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 38, pp. 13774-9, (2004) (PubMed).
: "Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex." dans: Human molecular genetics, Vol. 10, Issue 24, pp. 2821-31, (2001) (PubMed).
: "Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family." dans: The Journal of biological chemistry, Vol. 267, Issue 32, pp. 22699-702, (1992) (PubMed).
Synonymes et noms alternatifs relatifs à PSMC1
protease (prosome, macropain) 26S subunit, ATPase 1 (Psmc1), proteasome 26S subunit, ATPase 1 (PSMC1), proteasome 26S subunit, ATPase 1 (Psmc1), AI325227, P26s4, P26S4, p56, S4, s4Protein level used designations for PSMC1
- 26S protease regulatory subunit 4
- 26S proteasome AAA-ATPase subunit RPT2
- proteasome 26S subunit ATPase 1
- proteasome 26S ATPase subunit 1
- proteasome 26S subunit, ATPase, 1
- P26s4
- peptidase (prosome, macropain) 26S subunit, ATPase 1
- protease (prosome, macropain) 26S subunit, ATPase 1
- 26S ATPase complex subunit 4
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