PTPN11 Produits
(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
Catégories
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
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Catégories PTPN11 en vedette
PTPN11 Anticorps
High quality antibodies with extensive validation data.
PTPN11 Kits ELISA
Reliable ELISA kits for a wide range of species.
PTPN11 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PTPN11 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
IHC, ELISA, FACS, ICC
Validations
- (2)
- (6)
N° du produit
ABIN1098117
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (7)
N° du produit
ABIN3016707
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, FACS
Validations
- (6)
N° du produit
ABIN184604
Quantité
100 μg
Fiche technique
Fiche technique
PTPN11 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958958
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Analytical Method
Semi-Quantitative Cell ELISA
Validations
N° du produit
ABIN2747888
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380082
Quantité
2 x 96 tests
Fiche technique
Fiche technique
PTPN11 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1316822
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN7197591
Quantité
200 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7505167
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PTPN11
: "Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis." dans: Molecular immunology, Vol. 91, pp. 134-144, (2017) (PubMed).: "Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells." dans: Journal of Cancer, Vol. 6, Issue 2, pp. 151-9, (2015) (PubMed).
: "SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes." dans: PLoS ONE, Vol. 9, Issue 3, pp. e91582, (2014) (PubMed).
: "Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma." dans: Gut, Vol. 63, Issue 9, pp. 1457-67, (2014) (PubMed).
: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." dans: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).
: "A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells." dans: Blood, Vol. 118, Issue 6, pp. 1504-15, (2011) (PubMed).
: "Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis." dans: Cancer cell, Vol. 19, Issue 5, pp. 629-39, (2011) (PubMed).
: "Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway." dans: Journal of cellular biochemistry, Vol. 112, Issue 10, pp. 2837-49, (2011) (PubMed).
: "Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells." dans: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8003-12, (2010) (PubMed).
: "Mitochondrial DNA haplogroup 'R' is associated with Noonan syndrome of south India." dans: Mitochondrion, Vol. 10, Issue 2, pp. 166-73, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à PTPN11
protein tyrosine phosphatase, non-receptor type 11 (PTPN11), protein tyrosine phosphatase, non-receptor type 11 (Ptpn11), protein tyrosine phosphatase, non-receptor type 11 S homeolog (ptpn11.S), protein tyrosine phosphatase, non-receptor type 11, a (ptpn11a), protein tyrosine phosphatase, non-receptor type 11, b (ptpn11b), 2700084A17Rik, AW536184, BPTP3, bptp3, CFC, cfc, fa14b09, NS1, ns1, PTP-1D, ptp-2, PTP1D, PTP2C, ptp2c, ptpn11, ptpn11-a, ptpn11-b, SAP-2, SH-PTP2, SH-PTP3, SHP-2, shp-2, SHP2, Shp2, shp2, Syp, SYP, wu:fa14b09, wu:fi24f03, zgc:55388, zgc:63553Protein level used designations for PTPN11
- PTP-2C
- protein-tyrosine phosphatase 1D
- protein-tyrosine phosphatase 2C
- tyrosine-protein phosphatase non-receptor type 11
- SH2 domain-containing protein tyrosine phosphatase-2
- protein-tyrosine phosphatase SYP
- PTP-1D
- SH-PTP2 protein tyrosine phosphatase non-receptor type 11
- SH-PTP2 protein tyrosine phosphatase, non-receptor type 11
- SHP-2
- encodes catalytic domain
- protein tyrosine phosphatase SH-PTP2
- protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
- SH-PTP2
- cSH-PTP2
- non-receptor type protein tyrosine phosphatase SHP2
- phosphotyrosyl-protein phosphatase
- protein tyrosine phosphatase, non-receptor type 11 S homeolog
- LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11
- protein-tyrosine phosphatase SHP-2a
- protein tyrosine phosphatase, non-receptor type 11, b
- protein-tyrosine phosphatase SHP-2b
- shp3 protein
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