PTTG1 Produits
(Pituitary Tumor-Transforming 1 (PTTG1))
Catégories
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq, Jul 2008].
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Catégories PTTG1 en vedette
PTTG1 Anticorps
High quality antibodies with extensive validation data.
PTTG1 Kits ELISA
Reliable ELISA kits for a wide range of species.
PTTG1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PTTG1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
N° du produit
ABIN7444319
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF, FACS
Validations
- (5)
N° du produit
ABIN6391382
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (1)
- (3)
N° du produit
ABIN391532
Quantité
400 μL
Fiche technique
Fiche technique
PTTG1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6975309
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN5648205
Quantité
96 tests
Fiche technique
Fiche technique
PTTG1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124456
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316899
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316901
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PTTG1
: "Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis." dans: Annals of neurology, Vol. 86, Issue 1, pp. 99-115, (2019) (PubMed).: "Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment." dans: Acta biochimica et biophysica Sinica, Vol. 47, Issue 6, pp. 414-21, (2015) (PubMed).
: "Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13." dans: Tumour biology, (2015) (PubMed).
: "Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells." dans: Tumour biology, Vol. 35, Issue 9, pp. 8801-11, (2014) (PubMed).
: "PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population." dans: The Journal of biological chemistry, Vol. 287, Issue 23, pp. 19516-27, (2012) (PubMed).
Synonymes et noms alternatifs relatifs à PTTG1
pituitary tumor-transforming 1 (PTTG1), pituitary tumor-transforming gene 1 (Pttg1), pituitary tumor-transforming 1 (Pttg1), securin, sister chromatid separation inhibitor (cut2), AW555095, C87862, EAP1, HPTTG, Protein Cut2, PTTG, Pttg, PTTG1, Pttg3, securin, Securin, TUTR1Protein level used designations for PTTG1
- ESP1-associated protein 1
- pituitary tumor-transforming gene 1 protein
- securin
- tumor-transforming protein 1
- pituitary tumor-transforming protein 1
- pituitary tumor-transforming 1
- Pituitary tumor transforming
- Pituitary tumor-transforming gene 1 protein
- Cell untimely torn protein 2
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