PUMA Produits
(BCL2 Binding Component 3 (BBC3))
Catégories
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
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Catégories PUMA en vedette
PUMA Anticorps
High quality antibodies with extensive validation data.
PUMA Kits ELISA
Reliable ELISA kits for a wide range of species.
PUMA Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PUMA recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ICC, IF
Validations
- (6)
N° du produit
ABIN361748
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Pig, Rat
Application
WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (3)
- (4)
N° du produit
ABIN731528
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p), IF
Validations
- (1)
- (4)
N° du produit
ABIN388112
Quantité
400 μL
Fiche technique
Fiche technique
PUMA recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969127
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969126
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954053
Quantité
96 tests
Fiche technique
Fiche technique
PUMA recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7121980
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
N° du produit
ABIN2730162
Quantité
20 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7504951
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PUMA
: "Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation." dans: Cancer cell, Vol. 35, Issue 2, pp. 191-203.e8, (2019) (PubMed).: "Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis." dans: The Journal of biological chemistry, Vol. 294, Issue 35, pp. 12957-12974, (2019) (PubMed).
: "Inhibition of REST Suppresses Proliferation and Migration in Glioblastoma Cells." dans: International journal of molecular sciences, Vol. 17, Issue 5, (2017) (PubMed).
: "Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival." dans: The Journal of biological chemistry, Vol. 291, Issue 37, pp. 19545-57, (2016) (PubMed).
: "Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway." dans: Acta pharmacologica Sinica, Vol. 36, Issue 12, pp. 1514-9, (2016) (PubMed).
: "Detection of Bim and Puma in mouse hair follicles using immunofluorescence and TUNEL assay double staining." dans: Biotechnic & histochemistry : official publication of the Biological Stain Commission, pp. 1-7, (2015) (PubMed).
: "p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death." dans: Oncogene, (2015) (PubMed).
: "Nerve growth factor reduces apoptotic cell death in rat facial motor neurons after facial nerve injury." dans: Neurosciences (Riyadh, Saudi Arabia), Vol. 20, Issue 1, pp. 65-8, (2015) (PubMed).
: "B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins." dans: The Journal of biological chemistry, Vol. 289, Issue 38, pp. 26481-91, (2014) (PubMed).
: "A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53." dans: Cancer letters, Vol. 356, Issue 2 Pt B, pp. 910-7, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à PUMA
BCL2 binding component 3 (BBC3), Bcl-2 binding component 3 (Bbc3), BCL2 binding component 3 (Bbc3), BCL2 binding component 3 (bbc3), BBC3, JFY-1, JFY1, Puma, PUMA, PUMA/JFY1Protein level used designations for PUMA
- BCL2 binding component 3
- bcl-2-binding component 3
- p53 up-regulated modulator of apoptosis
- BH3-only
- Bcl-2 binding component 3
- Puma
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