Raet1d anticorps (PE)
Raet1d
Reactivité: Souris
FACS
Hôte: Souris
Monoclonal
Charlotte d1-23
PE
1 image
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- Antigène
- Raet1d (Retinoic Acid Early Transcript delta (Raet1d))
- Reactivité
- Souris
- Hôte
- Souris
- Clonalité
- Monoclonal
- Conjugué
- Cet anticorp Raet1d est conjugé à/à la PE
- Application
- Flow Cytometry (FACS)
- Purification
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- Clone
- Charlotte d1-23
- Isotype
- IgG1
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from prolonged exposure to light. Do not freeze.
- Stock
- 4 °C
- Stockage commentaire
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Antigène
- Raet1d (Retinoic Acid Early Transcript delta (Raet1d))
- Autre désignation
- RAE-1delta
- Synonymes
- anticorps RAE-1delta, anticorps retinoic acid early transcript delta, anticorps Raet1d
- Sujet
- RAE-1δ is one of the five RAE-1 family, GPI-linked membrane protein consisting of alpha, beta, gamma, delta, and epsilon. They are strong homology within the family, related by 92 % -95 % sequence identity. They are distantly related to MHC class I proteins. RAE-1 proteins are abundantly expressed in fetal tissues, but not in normal adult tissue. They are constitutively expressed on some tumors and can be induced by retinoid acid. Its ligand NKG2D is found on NK cells, many transformed cell lines, and LPS-stimulated peritoneal macrophages. The interaction of NKG2D with RAE-1 transmits stimulatory signals to NK cells and other hematopoietic cells, leading to enhanced proliferation, cytokine secretion and target killing. They are involved in the regulation of innate and immune cytotoxic responses to tumors, pathogen-infected cells, and autoimmune diseases.
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