Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

RASA1 Produits

(RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Catégories

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].

antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.

Catégories RASA1 en vedette

RASA1 Anticorps

High quality antibodies with extensive validation data.

RASA1 Kits ELISA

Reliable ELISA kits for a wide range of species.

RASA1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

RASA1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (4)
N° du produit ABIN562592
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Chicken, Dog, Frog, Human, Mouse, Rat
Application WB, IHC, IF, IP
Validations
  • (5)
  • (4)
N° du produit ABIN967706
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (3)
N° du produit ABIN519660
Quantité 100 μg
Fiche technique Fiche technique

RASA1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Goat
Analytical Method Competition ELISA
Validations
N° du produit ABIN995296
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Chicken
Analytical Method Competition ELISA
Validations
N° du produit ABIN1057985
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1154493
Quantité 96 tests
Fiche technique Fiche technique

RASA1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1317466
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1317464
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7416016
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits RASA1

Muto, Yi, Harrison, Dávalos, Fancher, Ziegler, Feigel, Kondo, Nishibe, Sessa, Dardik: "Eph-B4 prevents venous adaptive remodeling in the adult arterial environment." dans: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 561-75, (2011) (PubMed).

Cichowski, Santiago, Jardim, Johnson, Jacks: "Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor." dans: Genes & development, Vol. 17, Issue 4, pp. 449-54, (2003) (PubMed).

Sato, Ogata, De Luca: "Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells." dans: Oncogene, Vol. 19, Issue 25, pp. 2904-12, (2000) (PubMed).

Dupont, Blancq: "Formation of complexes involving RasGAP and p190 RhoGAP during morphogenetic events of the gastrulation in xenopus." dans: European journal of biochemistry / FEBS, Vol. 265, Issue 2, pp. 530-8, (1999) (PubMed).

Kaplan, Morrison, Wong, McCormick, Williams: "PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex." dans: Cell, Vol. 61, Issue 1, pp. 125-33, (1990) (PubMed).

Molloy, Bottaro, Fleming, Marshall, Gibbs, Aaronson: "PDGF induction of tyrosine phosphorylation of GTPase activating protein." dans: Nature, Vol. 342, Issue 6250, pp. 711-4, (1990) (PubMed).

Synonymes et noms alternatifs relatifs à RASA1

vacuolar peduncle (vap), RAS p21 protein activator 1 (RASA1), RAS p21 protein activator 1 (Rasa1), CG9209, CM-AVM, CMAVM, D-RasGAP, Dmel\\CG9209, GAP, Gap, GAPX, p120GAP, p120RASGAP, PKWS, RAS-GAP, RASA, Rasa, RasGAP, RasGap, rasGap, RASGAP

Protein level used designations for RASA1

  • CG9209-PA
  • CG9209-PB
  • CG9209-PC
  • CG9209-PD
  • Ras GTPase-activating protein
  • vacuolar peduncule
  • vacuolar pedunculi
  • vap-PA
  • vap-PB
  • vap-PC
  • vap-PD
  • ras GTPase-activating protein 1
  • triphosphatase-activating protein
  • GAP
  • GTPase-activating protein
  • RAS p21 protein activator (GTPase activating protein RAS p21)
  • p120GAP
  • rasGAP
  • RAS p21 protein activator 1
  • p120-rasGAP
Vous êtes ici:
Support technique