RASA1 Produits
(RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
Catégories
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].
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Catégories RASA1 en vedette
RASA1 Anticorps
High quality antibodies with extensive validation data.
RASA1 Kits ELISA
Reliable ELISA kits for a wide range of species.
RASA1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
RASA1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (4)
N° du produit
ABIN562592
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Chicken, Dog, Frog, Human, Mouse, Rat
Application
WB, IHC, IF, IP
Validations
- (5)
- (4)
N° du produit
ABIN967706
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
N° du produit
ABIN519660
Quantité
100 μg
Fiche technique
Fiche technique
RASA1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Goat
Analytical Method
Competition ELISA
Validations
N° du produit
ABIN995296
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Chicken
Analytical Method
Competition ELISA
Validations
N° du produit
ABIN1057985
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1154493
Quantité
96 tests
Fiche technique
Fiche technique
RASA1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1317466
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1317464
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7416016
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits RASA1
: "Eph-B4 prevents venous adaptive remodeling in the adult arterial environment." dans: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 561-75, (2011) (PubMed).: "Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor." dans: Genes & development, Vol. 17, Issue 4, pp. 449-54, (2003) (PubMed).
: "Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells." dans: Oncogene, Vol. 19, Issue 25, pp. 2904-12, (2000) (PubMed).
: "Formation of complexes involving RasGAP and p190 RhoGAP during morphogenetic events of the gastrulation in xenopus." dans: European journal of biochemistry / FEBS, Vol. 265, Issue 2, pp. 530-8, (1999) (PubMed).
: "PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex." dans: Cell, Vol. 61, Issue 1, pp. 125-33, (1990) (PubMed).
: "PDGF induction of tyrosine phosphorylation of GTPase activating protein." dans: Nature, Vol. 342, Issue 6250, pp. 711-4, (1990) (PubMed).
Synonymes et noms alternatifs relatifs à RASA1
vacuolar peduncle (vap), RAS p21 protein activator 1 (RASA1), RAS p21 protein activator 1 (Rasa1), CG9209, CM-AVM, CMAVM, D-RasGAP, Dmel\\CG9209, GAP, Gap, GAPX, p120GAP, p120RASGAP, PKWS, RAS-GAP, RASA, Rasa, RasGAP, RasGap, rasGap, RASGAPProtein level used designations for RASA1
- CG9209-PA
- CG9209-PB
- CG9209-PC
- CG9209-PD
- Ras GTPase-activating protein
- vacuolar peduncule
- vacuolar pedunculi
- vap-PA
- vap-PB
- vap-PC
- vap-PD
- ras GTPase-activating protein 1
- triphosphatase-activating protein
- GAP
- GTPase-activating protein
- RAS p21 protein activator (GTPase activating protein RAS p21)
- p120GAP
- rasGAP
- RAS p21 protein activator 1
- p120-rasGAP
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