(RAS Protein Activator Like 1 (GAP1 Like) (RASAL1))
Catégories
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010].
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Thaker, Raab, Strebhardt, Rudd: "GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity." dans: Nature communications, Vol. 10, Issue 1, pp. 4804, (2020) (PubMed).
Hong, Han, Wang, Gao, Li, Liu, Xia: "Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by regulating the expression of RASAL1/ERK1/2 signal pathway." dans: Journal of ethnopharmacology, Vol. 192, pp. 114-122, (2016) (PubMed).
Allen, Chu, Brill, Stotler, Buckler: "Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog." dans: Gene, Vol. 218, Issue 1-2, pp. 17-25, (1998) (PubMed).
Synonymes et noms alternatifs relatifs à RASAL1
RAS protein activator like 1 (RASAL1), RAS protein activator like 1 (rasal1), RAS protein activator like 1 (GAP1 like) (rasal1), RAS protein activator like 1 (GAP1 like) (Rasal1), RAS protein activator like 1 (Rasal1), MGC79606, MRASAL, RASAL, RASAL1, rasal1